Items by By NICHOLAS WADE
NYT > Health
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Rare Genetic Mutations May Underpin Diseases
Posted: May 17th, 2012, 10:08pm EDT by By NICHOLAS WADE
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Because the mutations are so rare, costly studies involving large numbers of patients would be needed to identify their role in each disease.
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Researchers Find Stem Cells Can Generate Human Eggs
Posted: February 27th, 2012, 1:17pm EST by By NICHOLAS WADE
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The advance from researchers at Massachusetts General Hospital could provide a new source of eggs for treating infertility.
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Y Chromosome, Though Diminished, Is Holding Its Ground
Posted: February 23rd, 2012, 1:47am EST by By NICHOLAS WADE
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The Y chromosome is just a fraction of its original size, and much smaller than its buxom partner, the X chromosome, but researchers say its gene-shedding days seem to be over.
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Wylie Vale Jr., Groundbreaking Endocrinologist, Dies at 70
Posted: January 15th, 2012, 11:57pm EST by By NICHOLAS WADE
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Dr. Vale helped identify the hormones through which the brain governs basic bodily functions and was involved in a combative race for the Nobel Prize.
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Fraud Charges for Dipak K. Das, a University of Connecticut Researcher
Posted: January 12th, 2012, 1:47am EST by By NICHOLAS WADE
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A charge of fraud involving 26 articles was leveled by the University of Connecticut against Dipak K. Das, whose work reported health benefits in red wine.
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Hemophilia B Gene Therapy Breakthrough
Posted: December 11th, 2011, 1:47am EST by By NICHOLAS WADE
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Hemophilia B is the first well-known disease to appear treatable by gene therapy, a technique with a 20-year record of almost unbroken failure.
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Hemophilia B Gene Therapy Breakthrough
Posted: December 11th, 2011, 1:47am EST by By NICHOLAS WADE
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Hemophilia B is the first well-known disease to appear treatable by gene therapy, a technique with a 20-year record of almost unbroken failure.
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Hemophilia B Gene Therapy Breakthrough
Posted: December 11th, 2011, 1:47am EST by By NICHOLAS WADE
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Hemophilia B is the first well-known disease to appear treatable by gene therapy, a technique with a 20-year record of almost unbroken failure.
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Hemophilia B Gene Therapy Breakthrough
Posted: December 11th, 2011, 1:47am EST by By NICHOLAS WADE
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Hemophilia B is the first well-known disease to appear treatable by gene therapy, a technique with a 20-year record of almost unbroken failure.
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In Body’s Shield Against Cancer, a Culprit in Aging May Lurk
Posted: November 22nd, 2011, 2:40pm EST by By NICHOLAS WADE
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Fat ebbs during aging when senescent cells remain. Research raises the possibility that attacks on the cells could postpone diseases of aging.Senescent cells seem to be a benign by-product of the body’s defense against cancer, but researchers are growing suspicious of their culpability in aging.
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Stem Cell Research Shows Promise
Posted: October 6th, 2011, 1:10am EDT by By NICHOLAS WADE
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Researchers from the New York Stem Cell Foundation Laboratory have, by lucky accident, found a way that stem cells can be harvested.
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Longevity Research Raises Hopes, and Questions
Posted: September 22nd, 2011, 1:30am EDT by By NICHOLAS WADE
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With a flurry of papers on the effects of proteins known as sirtuins, British and American researchers disagree on how to establish solid science in a relatively new field.
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Researchers Find Antibiotic Resistance in Ancient DNA
Posted: September 1st, 2011, 1:21am EDT by By NICHOLAS WADE
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The new finding underlines the need to use antibiotics sparingly, given that the genes for antibiotic resistance are ubiquitous and easily promoted by antibiotics.
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Sequencing the Microbe That Causes Bubonic Plague
Posted: August 30th, 2011, 4:20pm EDT by By NICHOLAS WADE
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Scientists are trying to sequence the genome of the bacterium that caused the Black Death from skeletons in a 14th-century graveyard in London.
NYT > Home Page
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Drug Is Found to Extend Lives of Obese Mice
Posted: August 18th, 2011, 10:42am EDT by By NICHOLAS WADE
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The drug, which mimics resveratrol, protected the mice from the usual diseases of obesity and helped them live 44 percent longer than other obese mice, researchers said.
NYT > Health
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Decoding DNA With Semiconductors
Posted: July 21st, 2011, 1:48am EDT by By NICHOLAS WADE
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The new Ion Torrent machine costs $49,000 and takes just two hours to sequence DNA, but its inventor says it will take years to make sense of much of the data it reveals.
NYT > Business
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Decoding DNA With Semiconductors
Posted: July 20th, 2011, 9:31pm EDT by By NICHOLAS WADE
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The new Ion Torrent machine costs $49,000 and takes just two hours to sequence DNA, but its inventor says it will take years to make sense of much of the data it reveals.
NYT > Health
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Genetic Code of E. Coli Is Hijacked by Biologists
Posted: July 15th, 2011, 12:30am EDT by By NICHOLAS WADE
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Harvard researchers devised a method for making hundreds of changes in the bacterium’s genome simultaneously, paving the way to replace the deleted genetic function with another.
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Roots of Disease Found to Vary by Continent
Posted: July 5th, 2011, 12:30am EDT by By NICHOLAS WADE
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A survey of the human genome shows that common diseases are likely to have a different set of genetic roots in Africans, East Asians and Europeans.
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Hippo, Warts and Other Thugs of the Genetic Realm
Posted: April 26th, 2011, 1:12am EDT by By NICHOLAS WADE
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The Hippo gene restraints the proliferation of heart cells in mice, left. Knock it out, and a heart grows to two and a half times bigger.Genes with colorful monikers may play a part in treating cardiac events.
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New View of How Humans Moved Away From Apes
Posted: March 14th, 2011, 2:10am EDT by By NICHOLAS WADE
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Anthropologists say early human groups would have been more cooperative and willing to learn from one another than the chimpanzees from which human ancestors split about five million years ago.
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Ecuadorean Villagers May Hold Secret to Longevity
Posted: February 17th, 2011, 1:33am EST by By NICHOLAS WADE
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People with a rare condition called Laron-type dwarfism are almost completely free of cancer and diabetes.
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Doubt on Anti-Aging Molecule as Drug Trial Stops
Posted: January 10th, 2011, 5:31pm EST by By NICHOLAS WADE
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There is a divergence of views on resveratrol, the minor ingredient of red wine that some researchers see as a drug that can extend life.
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Cancer Can Develop in Catastrophic Burst
Posted: January 10th, 2011, 4:40pm EST by By NICHOLAS WADE
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If a cell survives the disaster of a whole chromosome shattering, the cell may become cancerous, according to a new report.
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In Map of Brain Junction, Avenues to Answers
Posted: December 21st, 2010, 12:10am EST by By NICHOLAS WADE
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Researchers have identified the components of a critical part of the brain’s architecture: the synapse, or junction where one neuron makes a connection with another.
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Rare Hits and Heaps of Misses to Pay For
Posted: November 8th, 2010, 7:40pm EST by By NICHOLAS WADE
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Research is not the risk-free business that might easily be supposed from the promises of scientific spokesmen or the daily reports of new advances.
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Europe’s Plagues Came From China, Study Finds
Posted: November 1st, 2010, 11:30am EDT by By NICHOLAS WADE
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The waves of plague that twice devastated Europe and changed the course of history had their origins in China, a team of medical geneticists reported.
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New DNA Tests Aimed at Reducing Colon Cancer
Posted: October 29th, 2010, 2:44pm EDT by By NICHOLAS WADE
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The tests, which could help avoid many colonoscopies, are expected to be brought to market within two years.
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Strides Made Toward Early Diagnosing of Pancreatic Cancer
Posted: October 28th, 2010, 3:01am EDT by By NICHOLAS WADE
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A principal finding is that pancreatic tumors grow very slowly, creating an opportunity for detecting and removing the cancers at an early stage.
NYT > Home Page
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Pioneer of In Vitro Fertilization Wins Nobel Prize
Posted: October 4th, 2010, 11:49am EDT by By NICHOLAS WADE
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Robert G. Edwards of Britain won the prize in medicine for a breakthrough that has helped millions to have children.
NYT > Health
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Pioneer of In Vitro Fertilization Wins Nobel Prize
Posted: October 4th, 2010, 11:16am EDT by By NICHOLAS WADE
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Robert G. Edwards of Britain won the prize in medicine for a breakthrough that helped millions to have children.
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Rivalry Among DNA Sleuths Comes Alive in Letters
Posted: September 30th, 2010, 2:20am EDT by By NICHOLAS WADE
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The letters, written by and to Francis Crick over 26 years and thought to have been destroyed decades ago, surfaced among the papers of a former office mate.
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Natural Selection Cuts Broad Swath Through Fruit Fly Genome
Posted: September 21st, 2010, 1:12am EDT by By NICHOLAS WADE
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Fruit fly researchers showed that natural selection can change a species by making certain genes more common, rather than waiting for a powerful mutation to show up and sweep the species.
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Tug of War Pits Genes of Parents in the Fetus
Posted: September 13th, 2010, 5:30pm EDT by By NICHOLAS WADE
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It has long been suggested that a mother’s and father’s genes do not play exactly equal roles, and new research points to asymmetry that could be far more substantial than thought.
NYT > Home Page
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Harvard Researcher May Have Fabricated Data
Posted: August 28th, 2010, 2:00am EDT by By NICHOLAS WADE
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Marc Houser is on leave after being found “solely responsible” for eight counts of scientific misconduct.
NYT > Health
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DNA Test May Speed Colon Cancer Diagnosis
Posted: August 10th, 2010, 12:30am EDT by By NICHOLAS WADE
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A new generation of tests now in development would evaluate stool samples before a colonoscopy is called for.
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Two New Paths to the Dream: Regeneration
Posted: August 6th, 2010, 11:48pm EDT by By NICHOLAS WADE
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Researchers may be closer to finding a way for humans to regrow parts of the body from their own cells.
NYT > Home Page
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Two New Paths to the Dream: Regeneration
Posted: August 6th, 2010, 2:10am EDT by By NICHOLAS WADE
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Researchers may be closer to finding a way for humans to regrow parts of the body from our own cells.
NYT > Health
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Breast Milk Sugars Give Infants a Protective Coat
Posted: August 3rd, 2010, 1:55am EDT by By NICHOLAS WADE
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A large part of human milk that cannot be digested by babies coats the lining of a breast-fed infant’s intestine, protecting it from noxious bacteria.
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Potential Found in a New Approach to Alzheimer’s
Posted: July 24th, 2010, 6:32am EDT by By NICHOLAS WADE
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A scientific finding raises hopes in treating Alzheimer’s disease, as well as Huntington’s and Parkinson’s.
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Scientists Criticize Study on Genetics of Old Age
Posted: July 9th, 2010, 12:20am EDT by By NICHOLAS WADE
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They said an article in the journal Science saying that a test could predict who would live to extreme old age was probably incorrect.
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A Decade Later, Human Genome Project Yields Few New Cures
Posted: June 13th, 2010, 1:46am EDT by By NICHOLAS WADE
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The primary goal of the $3 billion Human Genome Project — to ferret out the genetic roots of common diseases and generate treatments — remains largely elusive.
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Hormones Tip Balance in Matters of Trust
Posted: June 9th, 2010, 11:40am EDT by By NICHOLAS WADE
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A discovery has opened the door to studying the mechanisms that guide social relationships and a sense of fairness.
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Synthetic Bacterial Genome Takes Over Cell
Posted: May 21st, 2010, 12:52am EDT by By NICHOLAS WADE
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J. Craig Venter called it a step toward making microbes from scratch, but some scientists criticize the approach.
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Research Offers Clue Into How Hearts Can Regenerate in Some Species
Posted: March 24th, 2010, 11:58pm EDT by By NICHOLAS WADE
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The path injured hearts take to heal in a kind of fish may help researchers looking into human heart disease.
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Disease Cause Is Pinpointed With Genome
Posted: March 11th, 2010, 6:14am EST by By NICHOLAS WADE
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It now appears possible to sequence a patient’s genome at reasonable cost and with sufficient accuracy to be useful.
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Speed Reading of DNA May Help Cancer Treatment
Posted: March 9th, 2010, 12:50am EST by By NICHOLAS WADE
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If altered bits of genetic material could be picked up in a patient’s bloodstream, they would serve as a direct and sensitive marker of cancer.
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Scientists Decode Genomes of Five Africans, Including Archbishop Tutu
Posted: February 17th, 2010, 3:18pm EST by By NICHOLAS WADE
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An analysis of four African Bushmen and the archbishop found 1.3 million novel DNA variants, an important step in expanding the study of genetic diversity.
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A New Way to Look for Diseases’ Genetic Roots
Posted: January 26th, 2010, 1:18am EST by By NICHOLAS WADE
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Though scientists hit a wall in their search, a Duke geneticist has ideas on how to renew the hunt.
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Male Chromosome Evolves Fastest of All, Study Finds
Posted: January 13th, 2010, 3:29pm EST by By NICHOLAS WADE
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The Y chromosome’s rapid rate of change does not mean men are evolving faster than women, but its innovation is likely having reverberations in the human genome.
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In New Way to Edit DNA, Hope for Treating Disease
Posted: December 29th, 2009, 1:39am EST by By NICHOLAS WADE
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Scientists might have a new way to alter human DNA if a technique for editing the genetic text proves safe and effective.
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New Stem Cell Lines Open to Research
Posted: December 3rd, 2009, 3:01am EST by By NICHOLAS WADE
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The action by the National Institutes of Health followed President Obama’s decision to change a policy set in the Bush administration.
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A Genetics Company Fails, Its Research Too Complex
Posted: November 18th, 2009, 11:23am EST by By NICHOLAS WADE
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The demise of deCode Genetics was largely the result of learning that researching genes that cause diseases was far more complex than anyone originally thought.
NYT > Business
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DeCode Genetics Files for Bankruptcy
Posted: November 17th, 2009, 6:47pm EST by By NICHOLAS WADE
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The company’s demise was largely the result of learning that researching genes that cause diseases was far more complex than anyone originally thought.
NYT > Health
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Speech Gene Shows Its Bossy Nature
Posted: November 12th, 2009, 2:25am EST by By NICHOLAS WADE
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Laboratory tests in which the chimp version of a speech gene was put into human neurons confirmed suspicions that FOXP2 is a maestro of the genome.
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3 Americans Share Nobel for Medicine
Posted: October 6th, 2009, 2:11am EDT by By NICHOLAS WADE
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Three scientists solved a longstanding puzzle of cell biology with deep relevance to cancer and aging.
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Quest for a Long Life Gains Scientific Respect
Posted: September 29th, 2009, 1:08am EDT by By NICHOLAS WADE
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David Sinclair, left, and Christoph Westphal, co-founders of Sitris Pharmaceuticals, in Dr. Sinclair’s laboratory in Cambrdge, Mass. The company develops drugs that mimic resveratrol, a chemical found in some red wines.Low-calorie diets and drugs that mimic their effects were all the rage at a Harvard Medical School conference on aging.
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With Genetic Gift, 2 Monkeys Are Viewing a More Colorful World
Posted: September 22nd, 2009, 11:43am EDT by By NICHOLAS WADE
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Scientists introduced a missing red pigment into the cone cells of the retinas of two male squirrel monkeys.
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Bathing, but Not Alone
Posted: September 15th, 2009, 12:42am EDT by By NICHOLAS WADE
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A deluge of bacteria hit your face and flow deep into your lungs in the morning shower.
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New Clues to Sex Anomalies in How Y Chromosomes Are Copied
Posted: September 15th, 2009, 12:38am EDT by By NICHOLAS WADE
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The Y chromosome has an Achilles’ heel that leads to a wide variety of sexual disorders.
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3 Genetic Variants Are Found to Be Linked to Alzheimer’s
Posted: September 6th, 2009, 10:53pm EDT by By NICHOLAS WADE
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The variants discovered by European scientists account for some 20 percent of the genetic risk of the disease.
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Tests Begin on Drugs That May Slow Aging
Posted: August 18th, 2009, 11:58am EDT by By NICHOLAS WADE
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Excitement among some researchers has picked up with the apparent convergence of lines of inquiry involving genes and restricted diets.
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Genes Tied to Gap in Treatment of Hepatitis C
Posted: August 17th, 2009, 2:45am EDT by By NICHOLAS WADE
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A Duke University team found that coding at a single site on the DNA helped explain why the standard drugs were more effective in whites than in blacks.
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Screening Could Lead to More Potent Cancer Drugs
Posted: August 14th, 2009, 1:06pm EDT by By NICHOLAS WADE
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Researchers have found a way to identify drugs that can specifically attack and kill cancer stem cells.
NYT > Home Page
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Cost of Decoding a Genome Is Lowered
Posted: August 10th, 2009, 4:05pm EDT by By NICHOLAS WADE
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A Stanford engineer used a new technology he invented to decode his own genome for less than $50,000.
NYT > Health
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Research Undermines Dog Domestication Theory
Posted: August 4th, 2009, 1:48am EDT by By NICHOLAS WADE
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Scientists had thought that dogs, like these in Tibet, were domesticated from wolves in East Asia, but new work calls that into question.A new report “leaves in disarray” the thesis that dogs evolved in East Asia, scientists say.
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Discovery May Help Treat Obesity
Posted: July 30th, 2009, 3:07pm EDT by By NICHOLAS WADE
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In a new study, researchers raise the possibility that if certain brown fat cells could be made more active, a person might burn more fat.
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Dieting Monkeys Offer Hope for Living Longer
Posted: July 10th, 2009, 12:42am EDT by By NICHOLAS WADE
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A study of monkeys suggests that people could in principle extend their life span by following a calorie-restricted diet.
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Antibiotic Delayed Aging in Experiments With Mice
Posted: July 9th, 2009, 10:39pm EDT by By NICHOLAS WADE
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The drug, rapamycin, has already been in use for suppressing the immune system in transplant patients.
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TierneyLab: Hoopla, and Disappointment, in Schizophrenia Research
Posted: July 1st, 2009, 5:28pm EDT by By NICHOLAS WADE
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Hoopla for new research on the genetics of schizophrenia is misplaced. The findings dash cold water on the hope of finding a simple genetic basis for the illness.
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In Worms, Genetic Clues to Extending Longevity
Posted: June 9th, 2009, 12:27pm EDT by By NICHOLAS WADE
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A study conducted on round worms may provide an explanation for recent experiments in which biologists have made laboratory organisms live longer by manipulating their genes.
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A Skeleton 4,000 Years Old Bears Evidence of Leprosy
Posted: May 27th, 2009, 2:10am EDT by By NICHOLAS WADE
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The oldest known skeleton showing signs of leprosy has been found in India and may help solve the puzzle of where the disease originated.
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Vitamins Found to Curb Exercise Benefits
Posted: May 12th, 2009, 1:37am EDT by By NICHOLAS WADE
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Antioxidants appear to short-circuit a natural response by the body.
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Genes Show Limited Value in Predicting Diseases
Posted: April 16th, 2009, 2:28am EDT by By NICHOLAS WADE
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The genetic analysis of common disease is turning out to be a lot more complex than expected, according to new commentary.
NYT > Home Page
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Genes Show Limited Value in Predicting Diseases
Posted: April 16th, 2009, 2:28am EDT by By NICHOLAS WADE
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The genetic analysis of common disease is turning out to be a lot more complex than expected, according to new commentary.
NYT > Health
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Evidence That Mice Produce Egg Cells After Birth
Posted: April 14th, 2009, 1:20am EDT by By NICHOLAS WADE
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Mice injected with fertility cells with a green marker had green offspring, indicating they originated from eggs produced by the injected cells.Scientists have challenged the orthodox medical view that a woman is born with egg cells to last a lifetime.
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Heart Muscle Renewed Over Lifetime, Study Finds
Posted: April 3rd, 2009, 9:38am EDT by By NICHOLAS WADE
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The finding upends a medical myth and suggests new therapies for heart attack patients may be possible.
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News Analysis: Rethink Stem Cells? Science Already Has
Posted: March 10th, 2009, 6:54pm EDT by By NICHOLAS WADE
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What impact will President Obama’s move to lift the ban on stem cell research have on current work?
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Converting Cells Shows Promise for Parkinson’s
Posted: March 6th, 2009, 2:13am EST by By NICHOLAS WADE
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Biologists have been able to convert skin cells into the type of neurons that are destroyed in the disease.
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Cure for the Common Cold? Not Yet, but Possible
Posted: February 13th, 2009, 3:04am EST by By NICHOLAS WADE
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Researchers said that they had decoded the genomes of the 99 strains of common cold virus.
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Gene Study Finds Link to Cancer of Thyroid
Posted: February 7th, 2009, 1:12am EST by By NICHOLAS WADE
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Scientists have identified two genetic variations that account for 57 percent of cases of thyroid cancer, a finding that could lead to earlier detection.
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A Coat of Many Proteins May Be This Parasite’s Downfall
Posted: December 15th, 2008, 11:33pm EST by By NICHOLAS WADE
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Scientists have learned how giardia dodges the immune system and are applying the knowledge to develop a potential vaccine.
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Scientists Find Clues to Aging in a Red Wine Ingredient’s Role in Activating a Protein
Posted: November 27th, 2008, 5:20am EST by By NICHOLAS WADE
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Researchers have discovered that a compound in red wine may reverse the chromosomal aging process.
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Scientist at Work | David B. Goldstein: A Dissenting Voice as the Genome Is Sifted to Fight Disease
Posted: September 16th, 2008, 12:12am EDT by By NICHOLAS WADE
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David B. Goldstein, a leading young population geneticist, says the effort to nail down the genetics of most common diseases is not working.
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Researchers Report Advances in Cell Conversion Technique
Posted: August 28th, 2008, 8:31am EDT by By NICHOLAS WADE
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Biologists at Harvard have converted cells from a mouse’s pancreas into the insulin-producing cells that are destroyed in diabetes.
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Drugs Offer Promise of Fitness Without Effort
Posted: July 31st, 2008, 6:32pm EDT by By NICHOLAS WADE
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Research on mice suggests that pills could trick the muscles into thinking they have been exercising.
NYT > Home Page
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Drugs Offer Promise of Fitness Without Effort
Posted: July 31st, 2008, 6:32pm EDT by By NICHOLAS WADE
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Research on mice suggests that pills could trick the muscles into thinking they have been exercising.
NYT > Health
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Gene-Hunters Find Hope and Hurdles in Schizophrenia Studies
Posted: July 31st, 2008, 1:04am EDT by By NICHOLAS WADE
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Researchers hunting for schizophrenia genes on a larger scale than ever before have found new genetic variants that point toward a different understanding of the disease.
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Hoping Two Drugs Carry a Side Effect: Longer Life
Posted: July 22nd, 2008, 9:25am EDT by By NICHOLAS WADE
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Sirtris, a drug company, has two drugs in clinical trials that it hopes will avert degenerative diseases of aging.
NYT > Business
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Hoping Two Drugs Carry a Side Effect: Longer Life
Posted: July 21st, 2008, 8:49pm EDT by By NICHOLAS WADE
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Sirtris, a drug company, has two drugs in clinical trials that it hopes will avert degenerative diseases of aging like diabetes, heart disease, cancer and Alzheimer’s.
NYT > Health
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Gene Variation May Raise Risk of H.I.V., Study Finds
Posted: July 17th, 2008, 2:30am EDT by By NICHOLAS WADE
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A genetic variation could account for 11 percent of the caseload of H.I.V. in Africa, explaining why the disease is more common there than expected, researchers say.
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Brainpower May Lie in Complexity of Synapses
Posted: June 9th, 2008, 11:34pm EDT by By NICHOLAS WADE
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A whole new dimension of evolutionary complexity for the brain has now emerged from a cross-species study.
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New Hints Seen That Red Wine May Slow Aging
Posted: June 5th, 2008, 1:20pm EDT by By NICHOLAS WADE
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Red wine may be much more potent than was thought in extending human life span, a new report suggests.
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Bacteria Thrive in Inner Elbow; No Harm Done
Posted: May 23rd, 2008, 1:55am EDT by By NICHOLAS WADE
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Even after you have washed the skin clean, there are still one million bacteria in every square centimeter of skin in the crook of your elbow. But they are not bad bacteria.